Öz

Amaç

Günümüzde, akut gastroenterit etkenleri arasında virüsler ilk sırada yer alırken, Rotavirüs (RV) ise akut viral gastroenteritlerin en sık etkenidir. Bu çalışma ile RV antijeni pozitif gastroenterit teşhisi ile çocuk servisinde yatırılan hastaların sosyo-demografik, klinik ve laboratuvar özelliklerinin literatür verileri ile kıyaslanarak yorumlanması amaçlandı.

Yöntem

RV gastroenteriti tanısı ile yatan hastaların sosyo-demografik verileri, klinik ve laboratuvar bulguları hastaneye ait dosya kayıtlarından geriye dönük incelenerek elde edildi.

Bulgular

Çalışmaya akut gastroenterit nedeni ile çocuk kliniğine yatırılan 740 hastadan yaş ortalaması 17,68 ay olan 270 RV pozitif saptanan olgu dahil edilmiş olup, RV oranı %36,5 olarak bulundu. Olgular en sık ilkbahar mevsiminde görülmekle birlikte en sık görüldüğü aylar ise Şubat, Mart ve Nisan ayları idi. En sık başvuru nedeni ishal ve kusma birlikteliği iken en sık görüldüğü yaş grubu 6 ay-2 yaş grubu idi. Beş hastada komplikasyon geliştiği tespit edildi. Laboratuvar bulgularından C-reaktif protein 101 hastada pozitif (%37,4), 213 hastada (%78,8) serum aspartat aminotransferaz düzeyi yüksek, 94 hastada (%34,8) alanin aminotransferaz düzeyi yüksek bulundu.

Sonuç

Servisimize yatırılan gastroenterit olgularının çoğunu RV ishalleri oluşturuyor olup, özellikle kış ve ilkbahar mevsimlerinde görülen önemli ishal nedenidir. Bu nedenle gastroenterit olgularında RV saptanması, hastanın kliniğinin öngörülmesi ve gereksiz antibiyotik kullanımının önüne geçilmesi bakımından önemlidir.

Anahtar Kelimeler: Anahtar kelimeler: Çocuk, gastroenterit, Rotavirüs

References

Tavakoli Nick S, Mohebbi SR, Ghaemi A, Hosseini SM. Human rotavirus in Iran; molecular epidemiology, genetic diversity and recent updates on vaccine advances. Gastroenterol Hepatol Bed Bench 2019;12(2):98-109.

Omatola CA, Olaniran AO. Rotaviruses: From Pathogenesis to Disease Control-A Critical Review. Viruses 2022;14(5):875.

Şay Coşkun US, Kasap T. Frequency of rotavirus and adenovirus in pediatric patients with acute gastroenteritis. J Contemp Med 2019;9(1):85-88.

Girish Kumar CP, Giri S, Chawla-Sarkar M, Gopalkrishna V, Chitambar SD, Ray P, et al. Epidemiology of rotavirus diarrhea among children less than 5 years hospitalized with acute gastroenteritis prior to rotavirus vaccine introduction in India. Vaccine 2020;38(51):8154-8160.

Asare EO, Al-Mamun MA, Sarmin M, Faruque ASG, Ahmed T, Pitzer VE. The influence of demographic and meteorological factors on temporal patterns of rotavirus infection in Dhaka, Bangladesh. Proc Biol Sci 2022;289(1976):20212727.

Wang LP, Zhou SX, Wang X, Lu QB, Shi LS, Ren X, et al. Etiological, epidemiological, and clinical features of acute diarrhea in China. Nat Commun 2021;12(1):2464.

Steele AD, Victor JC, Carey ME, Tate JE, Atherly DE, Pecenka C, et al. Experiences with rotavirus vaccines: can we improve rotavirus vaccine impact in developing countries?. Hum Vaccin Immunother 2019;15(6):1215-1227.

Ardura-Garcia C, Kreis C, Rakic M, Jaboyedoff M, Mallet MC, Low N, et al. Rotavirus disease and health care utilisation among children under 5 years of age in highly developed countries: A systematic review and meta-analysis. Vaccine 2021;39(22):2917-2928.

Zaraket R, Salami A, Bahmad M, Roz AE, Khalaf B, Ghssein G, et al. Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis. Heliyon 2020;6(6):e04248.

Burnett E, Parashar UD, Tate JE. Global Impact of Rotavirus Vaccination on Diarrhea Hospitalizations and Deaths Among Children <5 Years Old: 2006-2019. J Infect Dis 2020;222(10):1731-1739.

Troeger C, Khalil IA, Rao PC, Cao S, Blacker BF, Ahmed T, et al. Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years. JAMA Pediatr 2018;172(10):958-965. Erratum in: JAMA Pediatr 2022;176(2):208.

Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis 2006;12(2):304-306.

López-de-Andrés A, Jiménez-García R, Carrasco-Garrido P, Alvaro-Meca A, Galarza PG, de Miguel AG. Hospitalizations associated with rotavirus gastroenteritis in Spain, 2001-2005. BMC Public Health 2008;8:109.

Mathew MA, Paulose A, Chitralekha S, Nair MK, Kang G, Kilgore P. Prevalence of rotavirus diarrhea among hospitalized under-five children. Indian Pediatr 2014;51(1):27-31.

Ilktac M, Sahin A, Nazik H, Ongen B. Investigation of Rotavirus Frequency and Following up the Rotavirus Season among Children with Acute Gastroenteritis: Evaluation of Five-year Results. ANKEM Dergisi 2012;26(1):25-29.

Konca Ç, Tekin M, Akgün S, Bülbül M, Çoban M, Kahramaner Z, et al. Prevalence of rotavirus in children with acute gastroenteritis, seasonal distribution, and laboratory findings in the southeast of Turkey. J. Pediatr Inf 2014;8:7-11.

17. Ureña-Castro K, Ávila S, Gutierrez M, Naumova EN, Ulloa-Gutierrez R, Mora-Guevara A. Seasonality of Rotavirus Hospitalizations at Costa Rica's National Children's Hospital in 2010-2015. Int J Environ Res Public Health 2019;16(13):2321.

Van Damme P, Giaquinto C, Huet F, Gothefors L, Maxwell M, Van der Wielen M, et al. Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004-2005: the REVEAL study. J Infect Dis 2007;195(Suppl 1):S4-S16.

Carneiro NB, Diniz-Santos DR, Fagundes SQ, Neves LL, Reges RMB, Lima EKP, et al. Clinical and epidemiological aspects of children hospitalized with severe rotavirus-associated gastroenteritis in Salvador, BA, Brazil. Braz J Infect Dis 2005;9(6):525-528.

Staat MA, Azimi PH, Berke T, Roberts N, Bernstein DI, Ward RL, et al. Clinical presentations of rotavirus infection among hospitalized children. Pediatr Infect Dis J 2002;21(3):221-227.

Clark HF, Offit PA, Glass RI, Ward RL. Rotavirus. In: Plotkin SA, Orenstein WA Eds. Vaccines. 4th edition. Elsevier, Philadelphia. 2004:1327-1345.

Chiappini E, Azzari C, Moriondo M, Galli L, de Martino M. Viraemia is a common finding in immunocompetent children with rotavirus infection. J Med Virol 2005;76(2):265-267.

Wu TC, Liu HH, Chen YJ, Tang RB, Hwang BT, Yuan HC. Comparison of clinical features of childhood norovirus and rotavirus gastroenteritis in Taiwan. J Chin Med Assoc 2008;71(11):566-570.

Akelma AZ, Kütükoğlu I, Köksal T, Cizmeci MN, Kanburoğlu MK, Catal F, et al. Serum transaminase elevation in children with rotavirus gastroenteritis: seven years' experience. Scand J Infect Dis 2013;45(5):362-367.

Kang B, Kim DH, Hong YJ, Son BK, Kim DW, Kwon YS. Comparison between febrile and afebrile seizures associated with mild rotavirus gastroenteritis. Seizure 2013;22(7):560-564.

Hung JJ, Wen HY, Yen MH, Chen HW, Yan DC, Lin KL, et al. Rotavirus gastroenteritis associated with afebrile convulsion in children: clinical analysis of 40 cases. Chang Gung Med J 2003;26(9):654-659.

Scheier E, Aviner S. Septicemia following rotavirus gastroenteritis. Isr Med Assoc J 2013;15(3):166-169.

Gözmen S, Sükran Gözmen K, Apa H, Aktürk H, Sorguç Y, Bayram N, et al. Secondary bacteremia in rotavirus gastroenteritis. Pediatr Infect Dis J 2014;33(7):775-777.

Rotavirüs Gastroenterit Tanısı ile Kliniğimize Yatan Hastaların Sosyo-demografik Özellikleri, Klinik ve Laboratuvar Bulgularının İncelenmesi

Öz

References