Öz
Amaç
Akut pankreatitin ciddiyetini ve klinik sonuçları ile C-reaktif protein (CRP)/albümin oranı (CAO) arasındaki ilişkiyi belirlemeyi amaçladık.
Yöntem
İç hastalıkları kliniğinde yatırılarak tedavi gören toplam 580 akut pankreatitli hasta retrospektif olarak değerlendirildi. Hastalar revize Atlanta kriterlerine göre hafif, orta ve şiddetli pankreatit olarak 3 gruba ayrıldı. Bu gruplar arasında CAO, hastanede yatış süresi, yoğun bakım yatış ihtiyacı ve mortalite oranları karşılaştırıldı.
Bulgular
CAO şiddetli akut pankreatit ile ilişkili saptandı [olasılık oranı 1,04; %95 güven aralığı (GA): 1,03-1,06; p<0,001]. Atlanta kriterlerine göre şiddetli pankreatit hasta grubunu belirlemede CRP/albümin düzeyi %96,77 sensivite, %75,32 spesifite ile >15,59 olarak saptandı. Şiddetli akut pankreatitte CAO’nun ROC eğrisi altında kalan alan 0,89 (%95 GA: 0,87-0,92) idi. Albümin, CRP, CAO’nun Atlanta kriterlerine göre şiddetli hastalığı saptamada eğri altındaki alanlarını karşılaştırmada CAO, CRP’ye göre istatistiksel olarak anlamlı yüksek, albümin ile sınırda farklı saptandı.
Sonuç
Kolaylıkla bakılabilen ve non-invaziv bir test olan CAO akut pankreatitin ciddiyetini belirlemek için mevcut risk skorlarına ek olarak bir marker olarak kullanılabilir.
Anahtar Kelimeler: Anahtar kelimeler: Albümin, akut pankreatit, C-reaktif protein
Kaynakça
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