Öz
Amaç
Bu çalışmanın ana amacı, sitolojisi normal olan ve tip 16-18 dışı yüksek riskli human papilloma virüs (HPV) pozitifliği olan kadınlarda kolposkopinin rolünü değerlendirmektir.
Yöntem
Ocak 2018 ile Aralık 2023 tarihleri arasında kliniğe kolposkopi için başvuran kadınlardan oluşan bir kohort üzerinde retrospektif bir analiz yapılmıştır. Çalışmaya dahil edilen kadınların sitolojileri normaldi ve tip 16-18 dışı yüksek riskli HPV pozitifliği vardı. Demografik veriler ve kolposkopi sonuçları hasta dosyalarından ve jinekolojik onkoloji kliniğinin elektronik veri tabanından elde edildi.
Bulgular
Belirtilen dönem arasında toplam 1.646 kadına kolposkopi yapılmıştır. Dört yüz otuz (%26,1) kadında tip 16-18 dışı yüksek riskli HPV pozitifliği ve normal sitoloji saptandı. Kırk bir (%9,5) hastada servikal intraepitelyal neoplazi (CIN)2+ (CIN2,CIN2 ya da inavziv kanser) lezyon saptandı. CIN2+ lezyonu olan 41 kadının %22’sinde çoklu enfeksiyon, %17’sinde HPV diğer-x (alt grup tespit edilemedi), %17’sinde HPV tip 31 ve %12’sinde HPV tip 51 pozitifliği saptandı. CIN2+ lezyonların saptanma oranı HPV 31 pozitifliği olan kadın grubunda en yüksekti. HPV tip 31 pozitifliği olan kadınların sırasıyla %21,7’sinde (5/23) ve %8,7’sinde (2/23) servikal biyopsi ve endoservikal küretaj materyalinde CIN2 lezyonlar saptanmıştır.
Sonuç
Anormal sitolojisi olmayan ve tip 16-18 dışı yüksek riskli HPV taşıyan kadınlarda, yüksek dereceli servikal preinvaziv lezyon riski belirgin şekilde artmaktadır.
Anahtar Kelimeler: Anahtar kelimeler: İnsan papilloma virüsü, kolposkopi, serviks kanseri, servikal prekanseröz lezyonlar, servikal tarama
Kaynakça
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