Öz
Amaç
Uzun bekleme süresi ve yüksek ölüm oranı karaciğer nakli bekleyen hastalar için önemli sorunlardır. Canlı donör karaciğer naklinin (LDLT) uygulanabilirliğini artırmak için karaciğer donörü havuzunu genişletmek için birçok çaba sarf edilmektedir.
Yöntem
LDLT alıcılarında kullanılan canlı donörlerin farklı yaş gruplarında sağkalım üzerindeki etkisini incelemeyi planladık. Çalışma, LDLT geçiren hastaların retrospektif analizini içeriyordu. LDLT’ler birden fazla forma ayrıldı. Buna göre, üç farklı LD yaş grubu belirlendi: 18-39, 40-49 ve 50-59 yaş. Çalışmanın birincil çıktıları uzun vadeli alıcı ve greft sağkalımı ve erken alıcı komplikasyonlarıydı.
Bulgular
Donör yaş kategorisine göre gerçekleştirilen LDLT sayıları şu şekildeydi: 18-39 yaş (n=95), 40-49 yaş (n=46) ve 50-59 yaş (n=26). Birinci derece akraba oranı 50-59 yaş grubunda önemli ölçüde daha düşüktü. ≥%5 steatoz oranı (makro veya mikro) 50-59 yaş grubunda önemli ölçüde daha yüksekti (%42,3). Bir yıllık LDLT alıcı sağkalımı tüm gruplarda %100’dü. On sekiz-otuz dokuz, 40-49 ve 50-59 yaş gruplarının beş yıllık sağkalım oranları sırasıyla %100, %94,3 ve %86,7 idi. Ancak, 10 yıllık sağkalım oranı 18-39 yaş grubunda diğer gruplara göre önemli ölçüde daha yüksekti.
Sonuç
Alıcı ve greft sağkalım oranları beş yıla kadar yaş grupları arasında değişmedi. Alıcının bakış açısından, yaşlı LD kullanma kararı farklı LD seçenekleri veya DDLT bekleme süresi için risklerden daha ağır basmalıdır.
Anahtar Kelimeler: Anahtar kelimeler: Canlı karaciğer donör, donör yaşı, karaciğer nakli, sağkalım
Kaynakça
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